منابع مشابه
Comparison of the Initial Treatment Results of N-myc Positive and N-myc Negative Neuroblastoma Patients
Background: Neuroblastoma is the most common extra cranial malignant solid tumor of childhood. Various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. Over expression of the oncogen N-myc, is an important indicator of prognosis. Materials and Methods: Our study was performed from 20...
متن کاملMYC Immunohistochemistry Predicts MYC Rearrangements by FISH
MYC is the proto-oncogene classically associated with Burkitt lymphoma (BL) located at chromosomal locus 8q24. Rearrangements of MYC are seen in nearly 100% of BL but have been reported in 3-16% of diffuse large B-cell lymphomas (DLBCLs). Rearrangements of MYC are tested for by flourescence in situ hybridization (FISH). In this study, we compared immunohistochemistry (IHC) using a monoclonal an...
متن کاملc-Myc (Myc) and cancer literatures
c-Myc (Myc) is a regulator gene coding for a transcription factor. The c-Myc protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The mutated c-Myc is found in many cancers, which makes it be persistently expressed. This causes to the unregulated expression of many genes, some of which are involved in cell proli...
متن کاملThe human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
We have determined the nucleotide sequence and transforming activity of the human L-myc gene and a processed L-myc pseudogene (L-myc psi). We demonstrate by cotransformation assays that a 10.6-kb EcoRI fragment derived from a human placental library contains a complete and functional L-myc gene including transcriptional regulatory sequences sufficient for expression in rat embryo fibroblasts. O...
متن کاملDifferential apoptotic behaviors of c-myc, N-myc, and L-myc oncoproteins.
c-, N-, and L-myc are related nuclear oncoproteins that bind similar DNA sites and cooperate with activated ras oncogenes to transform primary fibroblasts. Although c-myc can also promote apoptosis in some cells after growth factor withdrawal or exposure to cytotoxic agents, roles for N- and L-myc in apoptosis remain undetermined. To address this, c-, N-, or L-myc were stably expressed in the i...
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(04)00336-8